Navigating the Day After Thanksgiving Crash: Understanding Tryptophan's Role
- Emily Cabrera
- Nov 27, 2025
- 3 min read
Thanksgiving is a day filled with delicious food, family gatherings, and often, a feeling of deep satisfaction. Yet, many people experience a sudden wave of fatigue the day after Thanksgiving. This "Thanksgiving crash" is commonly linked to tryptophan, an amino acid found in turkey. But is tryptophan really the cause of this post-holiday slump? This article explores the science behind tryptophan, what actually causes the day after Thanksgiving crash, and how to manage your energy during this festive season.

What Is Tryptophan and Why Is It Famous?
Tryptophan is an essential amino acid, meaning the body cannot produce it and must obtain it from food. It plays a key role in producing serotonin, a neurotransmitter that influences mood, sleep, and appetite. Serotonin can then convert into melatonin, a hormone that regulates sleep cycles.
Turkey contains tryptophan, which is why it often gets blamed for making people feel sleepy after a big Thanksgiving meal. However, turkey’s tryptophan content is not significantly higher than other common foods like chicken, beef, or cheese.
Why the Day After Thanksgiving Crash Happens
The feeling of exhaustion after Thanksgiving is not caused by tryptophan alone. Several factors contribute to this crash:
Large Meals: Thanksgiving meals tend to be large and rich in carbohydrates and fats. Digesting a heavy meal requires more blood flow to the stomach and intestines, which can leave you feeling tired.
High Carbohydrate Intake: Foods like mashed potatoes, stuffing, and pies increase insulin production. Insulin helps tryptophan enter the brain more easily, which can increase serotonin and melatonin levels, promoting sleepiness.
Alcohol Consumption: Many people enjoy wine, beer, or cocktails during Thanksgiving. Alcohol is a depressant and can amplify feelings of fatigue.
Disrupted Sleep Patterns: Holiday activities often lead to irregular sleep schedules, which can make you feel more tired the next day.
Relaxation and Reduced Activity: After a busy day of cooking and socializing, the body naturally wants to rest.
How Tryptophan Works in the Body
Tryptophan must compete with other amino acids to cross the blood-brain barrier. When you eat a balanced meal, tryptophan competes with other amino acids, limiting its effect on the brain. However, when you consume a meal high in carbohydrates, insulin lowers the levels of competing amino acids in the blood, allowing more tryptophan to enter the brain.
Once in the brain, tryptophan converts to serotonin, which can promote calmness and relaxation. This process explains why a carbohydrate-rich meal can make you feel sleepy, but it’s not the tryptophan in turkey alone causing this.
Managing the Post-Thanksgiving Fatigue
Understanding the causes of the Thanksgiving crash helps in managing it better. Here are some practical tips:
Eat Balanced Meals
Include protein, healthy fats, and fiber along with carbohydrates to slow digestion and reduce the insulin spike.
Stay Hydrated
Drinking water helps digestion and can reduce feelings of sluggishness.
Limit Alcohol
Enjoy alcoholic beverages in moderation to avoid excessive tiredness.
Take Short Walks
Light physical activity after meals can boost energy and aid digestion.
Prioritize Sleep
Try to maintain a regular sleep schedule before and after the holiday.
Alternatives to Combat the Crash
If you want to avoid the post-Thanksgiving slump, consider these alternatives:
Smaller Portions
Eating smaller servings throughout the day can prevent overwhelming your digestive system.
Include More Vegetables
Vegetables provide fiber and nutrients without causing a heavy insulin response.
Mindful Eating
Pay attention to hunger and fullness cues to avoid overeating.
Final Thoughts on Tryptophan and Thanksgiving Fatigue
The day after Thanksgiving crash is a real experience for many, but tryptophan in turkey is not the sole cause. The combination of a large, carbohydrate-rich meal, alcohol, and changes in activity and sleep patterns plays a bigger role. By understanding how tryptophan works and what factors contribute to fatigue, you can enjoy your holiday meals without the dreaded crash.
Try focusing on balanced meals, staying hydrated, and moving gently after eating to keep your energy steady. This way, you can savor the holiday spirit and feel ready for the days ahead.
If you’re interested in learning more about how nutrition, lifestyle habits, and integrative psychiatric care influence your overall well-being, visit www.dualmindspsychiatry.com for accessible resources and insight to support a healthier, more energized you.







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