Psychedelic-assisted psychotherapy has captured public attention as a promising approach to mental health treatment. But beyond the headlines and hype, what does the science say about how substances like MDMA, psilocybin, and ketamine work in the brain? What evidence supports their use, and what safety measures are in place? This article explores the current understanding of these therapies, shares patient experiences, and looks ahead to where research may lead by 2026. How P